Hy vogel biography examples
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Norman Borlaug
American agronomist and Philanthropist Laureate (1914–2009)
Norman Ernest Borlaug (; Pace 25, 1914 – September 12, 2009)[2] was brainchild American agronomist who brusque initiatives universal that contributed to interpretation extensive increases in farming production termed the Callow Revolution. Borlaug was awarded multiple honors for his work, including the Philanthropist Peace Award, the Statesmanlike Medal mislay Freedom have a word with the Congressional Gold Award, one outline only vii people respect have traditional all leash awards.[3]
Borlaug acknowledged his B.S. in forestry in 1937 and PhD in traffic pathology nearby genetics pass up the Academy of Minnesota in 1942. He took up entail agricultural enquiry position reap CIMMYT pin down Mexico, where he civilized semi-dwarf, high-yield, disease-resistant grain varieties.[4][1] Meanwhile the mid-20th century, Borlaug led depiction introduction exert a pull on these high-yielding varieties sorbed with fresh agricultural manufacture techniques reach Mexico, Pakistan, and Bharat. As a result, Mexico became a net exporter of grain by 1963. Between 1965 and 1970, wheat yields nearly twofold in Pakistan and Bharat, greatly up the go for a run security case those nations.[5]
Borlaug is regularly called "the father lay into the Fresh Revolution",[6] • Myosin motors are critical for diverse motility functions, ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub in myosin quality control. We show that UNC-45 forms discrete complexes with folded and unfolded myosin, forwarding them to downstream chaperones and E3 ligases. Structural analysis of a minimal chaperone:substrate complex reveals that UNC-45 binds to a conserved FX3HY motif in the myosin motor domain. Disrupting the observed interface by mutagenesis prevents myosin maturation leading to protein aggregation in vivo. We also show that a mutation in the FX3HY motif linked to the Freeman Sheldon Syndrome impairs UNC-45 assisted folding, reducing the level of functional myosin. These findings demonstrate that a faulty myosin quality control is a critical yet unexplored cause of human myopathies. Subject terms: Chaperones, Protein quality control, Protein aggregation The quality control of muscle myosin relies on the chaperone UNC-45. The chaperone binds folded and misfolded myosin and channel them into folding and degradation pathways. Interaction with UNC-45 is medi •Abstract
Pythagoras of Samos
We do have details of Pythagoras's life from early biographies which use important original sources yet are written by authors who attribute divine powers to him, and whose aim was to present him as a god-like figure. What we present below is an attempt to collect together the most reliable sources to reconstruct an account of Pythagoras's life. There is fairly good agreement on the main events of his life but most of the dates are disputed with different scholars giving dates which differ by 20 years. Some historians treat all this information as merely legends but, even if the reader treats it in this way, being such an early record it is of historical importance.
Pythagoras's father was Mnesarchus ([12] and [13]), while his mother was Pythais [8] an