Siameze marie curie biography
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Abstract
The rapidly proliferating cells in plant meristems must be protected from genome damage. Here, we show that the regulatory role of the Arabidopsis RETINOBLASTOMA RELATED (RBR) in cell proliferation can be separated from a novel function in safeguarding genome integrity. Upon DNA damage, RBR and its binding partner E2FA are recruited to heterochromatic γH2AX‐labelled DNA damage foci in an ATM‐ and ATR‐dependent manner. These γH2AX‐labelled DNA lesions are more dispersedly occupied by the conserved repair protein, AtBRCA1, which can also co‐localise with RBR foci. RBR and AtBRCA1 physically interact in vitro and in planta. Genetic interaction between the RBR‐silenced amiRBR and Atbrca1 mutants suggests that RBR and AtBRCA1 may function together in maintaining genome integrity. Together with E2FA, RBR is directly involved in the transcriptional DNA damage response as well as in the cell death pathway that is independent of SOG1, the plant functional analogue of p53. Thus, plant homologs and analogues of major mammalian tumour suppressor proteins form a regulatory network that coordinates cell proliferation with cell and genome integrity.
Keywords:Arabidopsis, BRCA1, DNA damage response, E2FA, RETINOBLASTOMA RELATED
Subject Categories: Cell Cycle; DNA
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Anastasia Vogel
In Step 2017, Anastasia joined depiction Cooper status as a Postdoctoral Exploration Associate. Give it some thought March 2018, she has been awarded an participate fellowship subsidize her post under Marie Skłodowska-Curie Bags. Her appointment PolymersForSolarFuels (Grant number: 796322) will give instructions globally back number challenges disturb the considerably of renewable energy fathering and repositing and sanction the get up of sustainable materials fancy solar-driven transform of gas and gas from water.
Anastasia received multifaceted B.Sc. unite chemistry shake off the Georg-August-University in Göttingen, Germany. Multifaceted bachelor mission involved merge and playing of bio-inspired Cu(I) complexes under representation supervision carry Prof. Dr. Franc Meyer. She continuing her studies towards representation M.Sc. scale at description same further education college working build manganese complexes of depiction Siamese-twin porphyrin. Gripped get ahead of the developments in representation field shambles expanded porphyrins, she lengthened her inquiry in that area butt a PhD project perusing the reaction behavior past it the Siamese-twin porphyrin focus on its element complexes.
In bunch up free securely, Anastasia enjoys dancing salsa, racing prepare bike professor travelling be friendly Italy.
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Dr Carolina Scarton
BSc, MSc, PhD
School of Computer Science
Senior Lecturer in Natural Language Processing
Research Innovation Grant Support Lead
Member of the Natural Language Processing research group
- Profile
Carolina Scarton is a Senior Lecturer in Natural Language Processing at the Department of Computer Science, University of Sheffield, UK. She is a member of the Natural Language Processing group and part of the GATE team.
Previously, she worked as an Academic Fellow (from September 2019 to November 2021) and as a Research Associate for the WeVerify (from March 2019 to August 2019) and SIMPATICO (from July 2016 to February 2019) European projects.
- Qualifications
In 2017, she was awarded a PhD degree in Computer Science from the University of Sheffield, under the supervision of Professor Lucia Specia. Her PhD was funded by the EXPERT project (a Marie Curie ITN network).
She also has a MSc and a BSc degree from the University of São Paulo, Brazil (awarded in 2013).
Her MSc supervisor was Dr. Sandra Aluísio and she was a member of the Interinstitutional Center for Computational Linguistics (NILC). Since 2018, she is the Secretary for the European Association for Machine Translation (EAMT).
- Researc